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Catatonia: From Psychopathology to Neurobiology

Edited by Stanley N. Caroff, M.D.,
Stephan C. Mann, M.D.,
Andrew Francis, M.D., Ph.D.,
and Gregory L. Fricchione, M.D.


During the 20th century, catatonia all but dropped off the agenda of mainstream psychiatric research. However, several dedicated research groups, represented in this volume, continued to report original data highlighting catatonia as a relevant and ideal subject for clinical study. This book, which exemplifies the unparalleled breadth of the knowledge gained, will benefit clinicians managing catatonic phenomena as well as researchers interested in pursuing further investigations.

This book covers in great detail the psychopathology and neurobiology of catatonia, focusing on the history, epidemiology, etiology, diagnosis and treatment of the disorder. This comprehensive volume

Offers a wide representation of the historical and worldwide literature on the many variants of catatonia in a single, well-organized text.

Includes work presented by the original investigators, many of whom work outside the United States and have had their previous studies published only in non-English journals.

Covers alternative opinions and perspectives on catatonia, contributing novel and illuminating perspectives on the syndrome.

Addresses areas of controversy—including disagreements over treatment and the nosologic status of catatonia—head-on, in a balanced, evidence-based presentation.

Balances practical clinical material with the underlying neurobiology, presenting clinical aspects in the context of history, epidemiology, cross-cultural perspectives, and neurobiological findings and highlighting the richness and intellectual attraction of the study of the disorder.
Catatonia is unique in offering a diverse, international group of contributors and such a comprehensive, up-to-date review of the clinical and scientific literature, spanning the breadth of contemporary understanding about the nature, meaning, and importance of the syndrome.


Preface. History. Epidemiology. Nosology. Clinical examination. Standardized instruments. Laboratory findings. Neuroimaging and neurophysiology. Periodic catatonia. Malignant catatonia. Medical catatonia. Drug-induced catatonia. Pharmacotherapy. Convulsive therapy. Prognosis and complications. Genetics. Animal models. Brain evolution and the meaning of catatonia. Index.


John Thomas Beld, M.D.
Peter Bräunig, M.D.
E. Cabrina Campbell, M.D.
Stanley N. Caroff, M.D.
Brendan T. Carroll, M.D.
Max Fink, M.D.
Andrew Francis, M.D., Ph.D.
Gregory L. Friccione, M.D.
Harold W. Goforth, M.D.
Robert A. Greenstein, M.D.
Stephen J. Kanes, M.D., Ph.D.
Stephanie Krüger, M.D.
Joseph W.Y. Lee, MBBS, MRCPsych, FRANZCP
James L. Levenson, M.D.
Antonio Lopez-Canino, M.D.
Chitra Malur, M.D.
Stephan C. Mann, M.D.
Michael F. Mazurek, M.D., FRCP(C)
Ann M. Mortimer, B.Sc., MBChB, FRCPsych, M.Med.Sc.
Georg Northoff, M.D., Ph.D.
Ananda K. Pandurangi, M.D.
Georgios Petrides, M.D.
Kemuel Philbrick, M.D.
Patricia I. Rosebush, M.Sc.N., M.D., FRCP(C)
Teresa Rummans, M.D.
Gerald Stöber, M.D.
Kenneth A. Sullivan, Ph.D.
Michael Alan Taylor, M.D.
Gabor S. Ungvari, M.D.


“This superb book provides a systematic and practical framework for the understanding of catatonia, a disorder on which we desperately need more research and understanding. It is written in a way that it is a uniform resource for both the student and advanced practitioner. Dr. Caroff and his team uniquely bring together current research as well as evidence-based treatment strategies for an illness that raises questions every time we make a diagnosis. The book is relevant for many types of professionals, including nonpsychiatric physicians, psychologists, nurses, social workers, and all those involved with research on this as well as related topics.”—Sanjay Gupta, M.D., Chairman, Department of Psychiatry, Olean General Hospital; President, Global Research and Consulting, Olean, New York; and Clinical Professor, Department of Psychiatry, University of Buffalo, School of Medicine and Biomedical Sciences, Buffalo, New York

“This book is an encyclopedic compendium, yet a highly readable summary of catatonia. It captures virtually every aspect of research regarding this syndrome, beginning with a history of its conceptualization, manifestations in medical and psychiatric disorders, treatment, and animal models. Clinicians should find this work an extremely helpful resource in the management of catatonia.”—Paul E. Keck Jr., M.D., Professor of Psychiatry, Pharmacology and Neuroscience, Vice Chairman for Research, University of Cincinnati College of Medicine, Cincinnati, Ohio

“The definitive textbook on catatonia, written and edited by the world's leading experts in neuropsychiatric movement disorders. A tour de force for clinicians and researchers alike.”—Arthur Lazarus, M.D., M.B.A., Senior Director of Clinical Research, AstraZeneca LP, and Professor of Psychiatry, Drexel University College of Medicine, Philadelphia, Pennsylvania

About the Authors

Dr. Stanley N. Caroff is Professor of Psychiatry at the University of Pennsylvania School of Medicine, and Chief of Inpatient Services at the Department of Veterans Affairs Medical Center, Philadelphia, Pennsylvania. He also serves as Director of the Neuroleptic Malignant Syndrome Information Service and is a member of the Board of Directors of the Malignant Hyperthermia Association of the United States.

Stephan C. Mann, M.D., is Professor of Psychiatry at the University of Pennsylvania School of Medicine and Director of Clinical Psychopharmacology at the Mental Health Clinic of the Department of Veterans Affairs Medical Center, Philadelphia, Pennsylvania. He also serves on the Professional Advisory Council of the Neuroleptic Malignant Syndrome Information Service.

Andrew Francis, Ph.D., M.D., is Associate Professor of Psychiatry at the State University of New York at Stony Brook School of Medicine, where he is Chief of Inpatient Services and Medical Director of the Day Treatment Program. He also serves on the Professional Advisory Council of the Neuroleptic Malignant Syndrome Information Service.

Gregory Fricchione, M.D., is Associate Professor of Psychiatry at the Harvard Medical School and Associate Chief of Psychiatry at Massachusetts General Hospital, where he also serves as Director of the Division of Psychiatry and Medicine and Director of the Division of International Psychiatry.

Ordering Information | Purchase

2004 · 248 pages · ISBN 1-58562-085-8 · Paperback · $53.00 · Item #62085

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