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24-HOUR MH HOTLINE: 800-644-9737
FOR EMERGENCIES ONLY

Will molecular genetic testing replace the caffeine halothane contracture test (CHCT) using biopsied muscle?

No. Not all MH susceptibles will, for the near future, have evidence of a DNA change. The CHCT by contrast is a very sensitive test, meaning that virtually all those with risk and susceptibility for MH will be detected by the contracture test. The genetic test will detect only about 30% of those at risk. However, the genetic test is very specific — that is, those with a positive test are virtually assured of being at risk for MH.

This item filed in the following categories:
  • Molecular Genetics
The mission of MHAUS is to promote optimum care and
scientific understanding of MH and related disorders.