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The technology for detecting DNA changes requires specialized equipment and expertise. Searching for so many DNA changes increases the cost. A special problem is that in MH, there is no single mutation responsible found in most patients who are MH susceptible. For example, in certain geographic vicinities, a single mutation may be found in up to 20% of families, but that same mutation might not be found in more than a small percent of susceptibles of a different ethnic group or located in a different geographic vicinity. By contrast, in a disorder such as Cystic Fibrosis, a single mutation is found in more than 80% of those afflicted.
Because of the expense of genetic testing and the low likelihood of a patient experiencing an MH episode, it is not economically feasible to screen all patients having surgery for MH.