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24-HOUR MH HOTLINE

800-644-9737

Outside NA: 001-209-417-3722
FOR EMERGENCIES ONLY

24-HOUR MH HOTLINE: 800-644-9737
Outside NA: 001-209-417-3722
FOR EMERGENCIES ONLY

Blog

Blog

Regular updates by our President, MHAUS staff, and guest contributors.

How many actually experience an MH episode? How many people are at risk for MH?
Dr. Henry Rosenberg MD, CPE
October 1, 2008

These direct and apparently straightforward questions have been posed for as many years as I have been involved in the study of MH.  If one checks the medical literature, the incidence of MH events ranges from one in 5,000 to one in 100,000 anesthetics.   That is quite a wide range.  In addition, how many people are at risk for MH is also unclear?

Comments (0)
How many actually experience an MH episode? How many people are at risk for MH?
Dr. Henry Rosenberg MD, CPE
October 1, 2008

These direct and apparently straightforward questions have been posed for as many years as I have been involved in the study of MH.  If one checks the medical literature, the incidence of MH events ranges from one in 5,000 to one in 100,000 anesthetics.   That is quite a wide range.  In addition, how many people are at risk for MH is also unclear?

Comments (3)
Past, Present and Future of Dantrolene
Dr. Henry Rosenberg MD, CPE
September 1, 2008

As all of you who are reading this know, dantrolene sodium is THE drug to treat malignant hyperthermia.  There are some important and interesting changes and insights developing with this drug that I would like to explore with you.

Comments (11)
The Malignant HyperthermiaS
Dr. Henry Rosenberg MD, CPE
August 1, 2008

The term Malignant Hyperthermia is most often applied to the syndrome that was first described in 1961 as a fatal reaction to general anesthesia. MH is the specific name given to the inherited disorder that leads individuals to develop a hypermetabolic reaction to certain general anesthetics and succinylcholine. And yes, a few individuals at risk for MH also experience problems resembling the MH syndrome with certain environmental stressors, such as heat and exercise. An MH reaction is terminated by the administration of dantrolene - a specific antidote for the MH reaction.

Comments (2)
Celebrating 25 years of the European MH Group (A Report on the most recent meeting)
Dr. Henry Rosenberg MD, CPE
June 24, 2008
Whenever I can, I try to attend the meeting of the European MH Group.  The group consists of many scientists and physicians who are actively investigating malignant hyperthermia and Central Core Disease and their relation to other muscle diseases.
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Celebrating 25 years of the European MH Group (A Report on the most recent meeting)
Dr. Henry Rosenberg MD, CPE
June 24, 2008
Whenever I can, I try to attend the meeting of the European MH Group.  The group consists of many scientists and physicians who are actively investigating malignant hyperthermia and Central Core Disease and their relation to other muscle diseases.
Comments (0)
Celebrating 25 years of the European MH Group (A Report on the most recent meeting)
Dr. Henry Rosenberg MD, CPE
June 24, 2008
Whenever I can, I try to attend the meeting of the European MH Group.  The group consists of many scientists and physicians who are actively investigating malignant hyperthermia and Central Core Disease and their relation to other muscle diseases.
Comments (0)
Malignant Hyperthermia Syndrome -- an International Problem
Dr. Henry Rosenberg MD, CPE
May 1, 2008

At the end of May many of the world's researchers and experts in the study of MH will gather in Lund, Sweden as part of the annual European MH Group meeting (see their web site at www.EMHG.org). The meeting will last three days and consist of updates and laboratory and clinical research and prospects for the future regarding MH.

This reminds me that MH is indeed an international problem and not limited to specific ethnic or religious groups. Wherever MH has been looked for, it has been found.

This post also available via the President's Blog Podcast.

Comments (0)
Malignant Hyperthermia Syndrome -- an International Problem
Dr. Henry Rosenberg MD, CPE
May 1, 2008

At the end of May many of the world's researchers and experts in the study of MH will gather in Lund, Sweden as part of the annual European MH Group meeting (see their web site at www.EMHG.org). The meeting will last three days and consist of updates and laboratory and clinical research and prospects for the future regarding MH.

This reminds me that MH is indeed an international problem and not limited to specific ethnic or religious groups. Wherever MH has been looked for, it has been found.

This post also available via the President's Blog Podcast.

Comments (5)
The (Re) Discovery of Malignant Hyperthermia
Dr. Henry Rosenberg MD, CPE
April 1, 2008

MH was first formally described in 1960 by physicians in Australia, including an anesthesiologist and a geneticist (Michael Denborough).  In recent years there has been greater and greater interest in MH by the medical community in general as well as basic scientists. The reasons for this are many, including the recognition that certain disorders of muscle predispose patients to MH, the concern that some MH patients may have muscle related problems without anesthesia, but one of the most important reasons is the growing interest in the subject of pharmacogenetics. 

 

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The mission of MHAUS is to promote optimum care and
scientific understanding of MH and related disorders.