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24-HOUR MH HOTLINE: 800-644-9737
FOR EMERGENCIES ONLY

Blog

Blog

Regular updates by our President, MHAUS staff, and guest contributors.

A Message from the President of MHAUS
Dr. Henry Rosenberg MD, CPE
March 1, 2008

My first post to the MHAUS President's Blog.  Come learn the basics of who and what MHAUS is. 

This post also available via the President's Blog Podcast.

Comments (4)
The (Re) Discovery of Malignant Hyperthermia
Dr. Henry Rosenberg MD, CPE
April 1, 2008

MH was first formally described in 1960 by physicians in Australia, including an anesthesiologist and a geneticist (Michael Denborough).  In recent years there has been greater and greater interest in MH by the medical community in general as well as basic scientists. The reasons for this are many, including the recognition that certain disorders of muscle predispose patients to MH, the concern that some MH patients may have muscle related problems without anesthesia, but one of the most important reasons is the growing interest in the subject of pharmacogenetics. 

This post also available via the President's Blog Podcast.

Comments (2)
The (Re) Discovery of Malignant Hyperthermia
Dr. Henry Rosenberg MD, CPE
April 1, 2008

MH was first formally described in 1960 by physicians in Australia, including an anesthesiologist and a geneticist (Michael Denborough).  In recent years there has been greater and greater interest in MH by the medical community in general as well as basic scientists. The reasons for this are many, including the recognition that certain disorders of muscle predispose patients to MH, the concern that some MH patients may have muscle related problems without anesthesia, but one of the most important reasons is the growing interest in the subject of pharmacogenetics. 

This post also available via the President's Blog Podcast.

Comments (0)
Malignant Hyperthermia Syndrome -- an International Problem
Dr. Henry Rosenberg MD, CPE
May 1, 2008

At the end of May many of the world's researchers and experts in the study of MH will gather in Lund, Sweden as part of the annual European MH Group meeting (see their web site at www.EMHG.org). The meeting will last three days and consist of updates and laboratory and clinical research and prospects for the future regarding MH.

This reminds me that MH is indeed an international problem and not limited to specific ethnic or religious groups. Wherever MH has been looked for, it has been found.

This post also available via the President's Blog Podcast.

Comments (5)
Malignant Hyperthermia Syndrome -- an International Problem
Dr. Henry Rosenberg MD, CPE
May 1, 2008

At the end of May many of the world's researchers and experts in the study of MH will gather in Lund, Sweden as part of the annual European MH Group meeting (see their web site at www.EMHG.org). The meeting will last three days and consist of updates and laboratory and clinical research and prospects for the future regarding MH.

This reminds me that MH is indeed an international problem and not limited to specific ethnic or religious groups. Wherever MH has been looked for, it has been found.

This post also available via the President's Blog Podcast.

Comments (0)
Are You Prepared for MH?
Dr. Henry Rosenberg MD, CPE
June 1, 2008

The death of Stephanie Kuleba from MH in March, 2008 during cosmetic surgery in an office-based operating room was a striking reminder that MH may occur wherever anesthesia is administered.  This event has caused anguish, pain and grief for the family and friends of this young woman as well as the providers of care.  This post also available via the President's Blog Podcast.

Comments (2)
Celebrating 25 years of the European MH Group (A Report on the most recent meeting)
Dr. Henry Rosenberg MD, CPE
June 24, 2008
Whenever I can, I try to attend the meeting of the European MH Group.  The group consists of many scientists and physicians who are actively investigating malignant hyperthermia and Central Core Disease and their relation to other muscle diseases.
Comments (0)
Celebrating 25 years of the European MH Group (A Report on the most recent meeting)
Dr. Henry Rosenberg MD, CPE
June 24, 2008
Whenever I can, I try to attend the meeting of the European MH Group.  The group consists of many scientists and physicians who are actively investigating malignant hyperthermia and Central Core Disease and their relation to other muscle diseases.
Comments (0)
Celebrating 25 years of the European MH Group (A Report on the most recent meeting)
Dr. Henry Rosenberg MD, CPE
June 24, 2008
Whenever I can, I try to attend the meeting of the European MH Group.  The group consists of many scientists and physicians who are actively investigating malignant hyperthermia and Central Core Disease and their relation to other muscle diseases.
Comments (0)
The Malignant HyperthermiaS
Dr. Henry Rosenberg MD, CPE
August 1, 2008

The term Malignant Hyperthermia is most often applied to the syndrome that was first described in 1961 as a fatal reaction to general anesthesia. MH is the specific name given to the inherited disorder that leads individuals to develop a hypermetabolic reaction to certain general anesthetics and succinylcholine. And yes, a few individuals at risk for MH also experience problems resembling the MH syndrome with certain environmental stressors, such as heat and exercise. An MH reaction is terminated by the administration of dantrolene - a specific antidote for the MH reaction.

Comments (2)
Past, Present and Future of Dantrolene
Dr. Henry Rosenberg MD, CPE
September 1, 2008

As all of you who are reading this know, dantrolene sodium is THE drug to treat malignant hyperthermia.  There are some important and interesting changes and insights developing with this drug that I would like to explore with you.

Comments (11)
How many actually experience an MH episode? How many people are at risk for MH?
Dr. Henry Rosenberg MD, CPE
October 1, 2008

These direct and apparently straightforward questions have been posed for as many years as I have been involved in the study of MH.  If one checks the medical literature, the incidence of MH events ranges from one in 5,000 to one in 100,000 anesthetics.   That is quite a wide range.  In addition, how many people are at risk for MH is also unclear?

Comments (3)
How many actually experience an MH episode? How many people are at risk for MH?
Dr. Henry Rosenberg MD, CPE
October 1, 2008

These direct and apparently straightforward questions have been posed for as many years as I have been involved in the study of MH.  If one checks the medical literature, the incidence of MH events ranges from one in 5,000 to one in 100,000 anesthetics.   That is quite a wide range.  In addition, how many people are at risk for MH is also unclear?

Comments (0)
How many people are at risk for MH?
Dr. Henry Rosenberg MD, CPE
October 1, 2008
By MHAUS President Henry Rosenberg, MD, CPE   How Many People at Risk: These direct and apparently straightforward questions have been posed for as many years as I have been involved in the study of MH. If one checks the medical literature, the incidence of MH events ranges from one …
Comments (0)
Malignant Hyperthermia: It's Not Just About Anesthesia
Dr. Henry Rosenberg MD, CPE
November 1, 2008
By MHAUS President Henry Rosenberg, MD, CPE   MH and Anesthesia: It is very common to think about the Malignant Hyperthermia (MH) syndrome as a problem related to anesthesia exclusively. Indeed most of the concerns about MH since its first descriptions in the 1960s centered on the unexpected and often …
Comments (0)
Malignant Hyperthermia: It's Not Just About Anesthesia
Dr. Henry Rosenberg MD, CPE
November 7, 2008

It is very common to think about the Malignant Hyperthermia (MH) syndrome as a problem related to anesthesia exclusively. Indeed most of the concerns about MH since its first descriptions in the 1960s centered on the unexpected and often disastrous changes that can occur during the administration of general anesthesia to an otherwise healthy individual.

Comments (16)
MHAUS: The Year 2008 in Review
Dr. Henry Rosenberg MD, CPE
December 15, 2008
The fact that I am writing this message in December of 2008 and can tell you that we are an organization that continues to be sought out by thousands for advice and information is pretty remarkable given the fact that a wide variety of large, wealthy organizations are foundering or have gone under. Furthermore we are planning new and innovative educational and patient service programs. 
Comments (0)
The Year Ahead for MHAUS-2009
Dr. Henry Rosenberg MD, CPE
January 8, 2009
As the New Year begins, it is customary to look ahead and plan and predict what is likely to occur in the coming 12 months. It’s always dangerous to engage in such predictions, but nevertheless, here are my thoughts.
Comments (0)
The Epidemiology of MH in the United States and Two New MHAUS Programs of Interest
Dr. Henry Rosenberg MD, CPE
February 11, 2009
As I mentioned in my last blog, one of the important questions regarding MH is the incidence of and the mortality from MH. Two recent studies are addressing these questions. One has been published, the other is in review.
Comments (1)
A New Advance in the Understanding of MH: What it May Mean for the Diagnosis of MH
Dr. Henry Rosenberg MD, CPE
March 18, 2009
Those of you who are reading this blog probably know that one of the major accomplishments related to MH in recent years has been the introduction of a DNA test, usually obtained by a blood sample, to diagnose MH susceptibility.  Three  laboratories offer such testing , two for the general public and one for the military.
Comments (2)
The mission of MHAUS is to promote optimum care and
scientific understanding of MH and related disorders.