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Blog
Regular updates by our President, MHAUS staff, and guest contributors.
The claims and opinions expressed in website blogs are those of the authors and not necessarily the views or opinions of MHAUS, its staff or its advertisers.
Abstract: We present the novel case report of a child with hypotonia and dysmorphic features who developed malignant hyperthermia (MH) intraoperatively. Neurology workup revealed the presence of a known causative ryanodine receptor (RYR1) mutation for MH, c.7522C>T; p.R2508C. Furthermore, the neurology workup diagnosed the child with King-Denborough syndrome (KDS). This …
Long term oral Dantrolene Improved Muscular Symptoms in a Malignant Hyperthermia Susceptible Individual. Butala, BN, Kang, A, Guron, J, & Brandom, BW. Journal of Neuromuscular Diseases, 2016. Dantrolene is a medication used for the treatment of acute malignant hyperthermia (MH) events as well as for chronic muscle spasms in some …
Dr. Beverly Britt was a very significant contributor to important discoveries about malignant hyperthermia during her Professorship at the University of Toronto. Beverly was a dear friend of mine and was helpful to me as I started my career working with physicians; especially anesthesiologists. Beverly died at her home in …
From 2011 through 2015, CMS inspection findings at various health systems revealed "deficiencies" related to MH preparedness. ARE YOU READY FOR MH Consider bringing one of MHAUS’ MH Experts to your facility to assure your plan of action is designed to address all areas of concern and you are …
Werneid, K., & Brandom, B. (2016). Survey of Long-Term Sequelae in Survivors of a Malignant Hyperthermia Reaction. Open Journal of Anesthesiology, 06(01), 1–7. http://doi.org/10.4236/ojanes.2016.61001 When researching malignant hyperthermia, there is ample information on causes, signs, symptoms, treatments, etc. Until now, there have been no studies examining any long term sequelae …
Butala, B. N., Kang, A., Guron, J., & Brandom, B. W. (2016). Long term oral Dantrolene Improved Muscular Symptoms in a Malignant Hyperthermia Susceptible Individual. Journal of Neuromuscular Diseases, 3(1), 115–119. http://doi.org/10.3233/JND-150130 A recent case report presented a patient with a significant family history of MH who had frequent symptoms …
Ramesh M. Singa MD, MHS; Cristina G. Pamaar MD Department of Anesthesiology and Perioperative Medicine, Saint Barnabas Medical Center, Livingston, NJ 07039 American and Filipino forces came together in Iloilo City, Philippines, on 8 January 2016. The group of healthcare professionals from the United States was led by Saint …
Reprinted with permission from Outpatient Surgery Magazine Marsha Thornhill, MD, the director of anesthesia at the Teaneck (N.J.) Surgical Center, helped save an 18-year-old patient’s life 7 years ago. The patient was having a rhinoplasty at a 1-room office-based plastic surgery center. The case was going very well, Dr. Thornhill …
By Henry Rosenberg, MDMHAUS PresidentThe year 2015 was another busy, productive year for MHAUS. Dianne Daugherty, our executive director, and her staff deserve special compliments for ensuring that MHAUS runs smoothly and meets the goals and objectives set forth by the Board of Directors. New programs are introduced on a …
Natalia Kraeva, PhD, MH investigation unit, Toronto, Canada The MHIU in Toronto, Canada has got a replacement for the CHCT apparatus, which had been used for the MH diagnosis for more than 35 years. The new MH measuring system, custom built for us by Biegler Medizinelektronik, Austria, fully complies …
Use of RYANODEX with Current Standard of Care (SOC) Showed Substantial Evidence of Increased Effectiveness in Treating EHS than SOC Alone Favorable Safety Data Shows No Significant Drug-Related Adverse Events in Patients Treated with RYANODEX Release Date: Thursday, December 17, 2015 6:50 am EST Dateline: WOODCLIFF LAKE, N.J. Public Company …
Merck’s BRIDION® (sugammadex) Receives FDA Approval for the Reversal of Neuromuscular Blockade Induced by Rocuronium and Vecuronium in Adults Undergoing Surgery KENILWORTH, N.J., Dec.17, 2015 – Merck (NYSE: MRK), known as MSD outside the United States and Canada, announced today that the U.S. Food and Drug Administration (FDA) has approved …
Genetic testing for susceptibility to Malignant Hyperthermia is already offered by a number of commercial laboratories (see the MHAUS web site for details). A new laboratory, the Robert Guthrie Biochemical and Molecular Genetics Laboratory at Buffalo General Medical Center, Buffalo, New York is now offering genetic testing for MH …
Succinylcholine (Anectine) is an MH trigger. Generally injected intravenously, the drug is usually used to produce deep muscle relaxation in order to facilitate such procedures as intubation of the trachea. The onset of relaxation is very rapid and the duration is generally less than 10 minutes. Succinylcholine, introduced in the …
Please read this wonderful article about Dr. Rosenberg, the President of MHAUS. Dr. Rosenberg is receiving an award this year at the American Society of Anethesiologists Annual Meeting. Join MHAUS in honoring Dr. Henry Rosenberg as he receives the ASA's Distinguished Service Award on October 24, 2015 in San Diego, …
My name is Brooke DiIanni and I am a graduate student in the nurse anesthesia program at the University Pittsburgh. As part of our didactic curriculum we are afforded the opportunity to work side by side with a researcher and become personally involved with a research entity. Malignant Hyperthermia (MH) …
As an undergraduate, I participated as a research assistant for a study on dementia. It was mostly data entry and busy work. When we were told we had to volunteer for a research project as part of our research practicum, I thought it would be more data entry. A classmate …
The annual meeting of the European MH group took place in the charming city of Lille, France. About 80 physicians, scientists, students and clinicians who are studying the problem of malignant hyperthermia attended, giving 41 presentations. Attendees came from many countries inside and outside Europe including the Soviet Union, South …
The National Institute of Nursing Research (NINR) at the National Institutes of Health (NIH) in Bethesda, Maryland, is conducting a research study to determine if a drug that has been approved by the FDA for other indications reduces the severity of some symptoms in people with ryanodine receptor 1-related myopathy …
Hendrik L. Dhaese", Patrick R. Martens8, Nicolas H. Miiller8, Isabelle M. Casier", Jan Paul J. Muliera and Luc Heytensb aDepartment of Anesthesiology, Intensive Care and Emergency Medicine, AZ Sint-Jan Brugge-Oostende AV, Campus Brugge, Brugge and "Universiteit Antwerpen, Campus Drie Eiken, Universiteitsplein 1, Wilrijk, Belgium Correspondence to Hendrik Dhaese, MD, Department …