YouTube Rap on the Pathophysiology of Malignant Hyperthermia

I'm Nick and this is Brandon,
We're here to teach a lesson.
Malignant Hyperthermia is what we'll be stressing.
So sit back and listen, this wont take too long,
We've made it all rhyme and put it into a song.

Impulses from the cortex, go down the spinal cord next
Continue through the nerve root, synapsing with a muscle group.
Ach binding lets sodium in the cell,
Causing the sarcolemma action potential
Electrical charge changes DHPR's way,
Puts RYR1 into action with no delay.
These are just the basics, your review for today
The primary motor, corticospinal pathway.

Genetic deviation in transcription and translation
Receptor mutation cause a deadly situation, yeah.
Ya gotta keep em cool.

RYR1 receptor for ryanodine
On the sarcoplasmic reticulum is where I mean
The receptor controls release of calcium stores
But with Malignant Hyperthermia it doesn't close its doors.
The calcium exposes binding sites on actin,
Then ATP and myosin form an attraction.
ATP hydrolis causes muscle contraction,
This is how your muscles are called to into action.

But too much calcium can be a bad thing. When all of your muscles are contracting. The SERCA pump and MYOSIN both use ATP Causing hyperthermia from the use of energy.

Genetic deviation in transcription and translation
Receptor mutation cause a deadly situation, yeah.
Ya gotta keep em cool.

As ATPs depleted within the muscle cell,
Metabolism causes CO2 to rise as well.
Sympathetic stimulus increase the heart rate
With no intervention death with surely be your fate.

Genetic deviation in transcription and translation
Receptor mutation cause a deadly situation, yeah.
Ya gotta keep em cool.

Malignant hyperthermia, from gene expression
If you're the Nurse Anesthetist you'll probably be stressing
If you pushed succs or uses volatile gases
You have to move fast, not slow like molasses

First you see a rapid rise in CO2
That your poor patients breathing back at you
From increased metabolism and exhausted ATP
The SERCA tried its best, now its up to you, you see.
Eliminate inhalants, and crank up the O2
Get some help STAT and start an A-line too.
You have to keep both you and your patient cool.
Hyperventilate your patient, not yourself fool.

Genetic deviation in transcription and translation
Receptor mutation cause a deadly situation, yeah.
Ya gotta keep em cool.

Malignant Hyperthermia is what I mean,
The only known antidote is Dantrolene.
It inhibits efflux of calcium ion
That is causing the cells depolarization.
2.5 mg a kilogram of weight,
Repeat in 10 minutes if the symptoms don't abate
Push it hard and fast and everything should be great.
And follow ABGs so all your treatments correlate.

We hope you can groove to this in depth physiology
Mid-wives, FNPs and those in psychology
Do whatever dance goes with a beat like this
Get your backside doing ATP hydrolysis

Gotta keep them cool
keep em cool