Long Term Oral Dantrolene Improved Muscular Symptoms in a Malignant Hyperthermia Susceptible Individual

Long term oral Dantrolene Improved Muscular Symptoms in a Malignant Hyperthermia Susceptible Individual.

Butala, BN, Kang, A, Guron, J, & Brandom, BW. Journal of Neuromuscular Diseases, 2016.

Dantrolene is a medication used for the treatment of acute malignant hyperthermia (MH) events as well as for chronic muscle spasms in some patients. There have been cases of patients taking dantrolene for short term or episodic muscular symptoms possibly related to MH. The patient in this case report had a well-documented family history of MH episodes as well as carried a genetic mutation in her ryanodine receptor type 1 gene. The patient took low-dose oral dantrolene for over 25 years for chronic muscle pain symptoms with great relief. She experienced no side effects of the medication. ~ Brian Butala, DO - Allegheny Health Network, Pittsburgh, PA