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24-HOUR MH HOTLINE

800-644-9737

Outside NA: 001-209-417-3722
FOR EMERGENCIES ONLY

24-HOUR MH HOTLINE: 800-644-9737
Outside NA: 001-209-417-3722
FOR EMERGENCIES ONLY

Blog

Blog

Regular updates by our President, MHAUS staff, and guest contributors.

Another Unusual and Disturbing Malignant Hyperthermia Death
MHAUS Staff
June 25, 2012

A few months ago, I received an unusual call from the MH Hotline who connected me to an anesthesiologist and OR team who were desperately trying to manage a Malignant Hyperthermia crisis. They were frantic and clearly trying to stabilize a patient experiencing a severe MH episode. The patient was an athletic older teenager undergoing an elective orthopedic surgical procedure on the ankle. Anesthesia was being conducted with the commonly used gas anesthetic sevoflurane and Succinylcholine had not been used.

Comments (30)
Succinylcholine Dantrolene Controversy
MHAUS Staff
May 30, 2012
Succinylcholine (also called Anectine) is a drug that has been in use for over half a century by anesthesia providers, emergency medicine physicians, critical care physicians and others when they wish to produce paralysis that is rapid in onset but lasts for only a few minutes.
Comments (12)
Comment on Mitochondrial Myopathy and Malignant Hyperthermia
MHAUS Staff
May 9, 2012
Topic: Does Mitochondrial Myopathy (MM) Increase an Individual's Susceptibility to Malignant Hyperthermia (MH)   Please Comment on the Following Recommendations by June 9, 2012 Review of literature does not indicate an increased susceptibility to MH by patients diagnosed with Mitochondrial Myopathy (MM). Patients suffering from MM should receive an anesthetic …
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Grey’s Anatomy and a Potpourri of other News
MHAUS Staff
January 24, 2012

In the episode, the young patient undergoing emergency surgery develops elevated levels of carbon dioxide, increased heart rate and elevated temperature. The anesthesiologist recognizes the signs and informs the team of the problem.  One of the OR personnel is dispatched to obtain ice and the anesthesiologist whips out a vial of dantrolene, injects it and waits for the signs of MH to respond.

Comments (3)
A New Drug for Heat Stroke? Implications for Malignant Hyperthermia
MHAUS Staff
January 12, 2012
While their common triggers may differ, the signs associated with MH and heat stroke are remarkably similar – uncontrolled muscle contractions, dangerous increases in body temperature, and muscle breakdown leading to the release of toxins in the blood which may cause cardiac arrhythmias and death.
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'Couch Potato' Pill Prevents Heat Stroke, Study Finds
MHAUS Staff
January 9, 2012
Scientists have stumbled upon a drug that may prevent heat stroke for people prone to the deadly condition. Ironically, it’s the same drug flaunted three years ago as the “couch potato pill” for its ability to build muscle and increase endurance in mice that never break a sweat.
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Best Wishes for the Holidays and New Year
Dr. Henry Rosenberg MD, CPE
December 28, 2011

At this joyous time of the year, I would like to wish all the friends and supporters of MHAUS best wishes for the holidays and the New Year. Your support and encouragement of our activities and programs motivates the entire team to continue to bring the latest information and educational programs to those with an interest in this complex, potentially fatal disorder first described over 50 years ago.

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"Awake" MH
Dr. Henry Rosenberg MD, CPE
November 21, 2011

From the beginning descriptions of the MH syndrome in the 1960s it was noted that the animal model for MH, i.e. certain pig breeds would develop muscle breakdown, acidosis, and high body temperature with stress alone (“awake MH”, i.e. MH signs without exposure to anesthetic agents).

Comments (16)
Thirtieth Anniversary of MHAUS
Dr. Henry Rosenberg MD, CPE
October 26, 2011

1981 was a rather important year in my professional life. On July first I assumed the Chairmanship of Anesthesiology at Hahnemann University in Philadelphia. In October 1981 the first meeting of what would turn out to be the founding Board of MHAUS met in my unfinished offices at Hahnemann.  It is hard to believe that thirty years have gone by which witnessed the evolution of a patient advocacy organization from an unknown entity to one where anyone seeking information and guidance on MH turns first.

Comments (1)
New Emergency Therapy for MH Poster
MHAUS Staff
October 1, 2011
Updates have been made to the Emergency Therapy for MH Poster effective September 2011.  Be prepared, order yours today! …
Comments (8)
2010 Scientific Conference Proceedings Ready
MHAUS Staff
September 30, 2011
This document is a collection of summaries prepared from information presented by the speakers at the MHAUS Scientific Conference held at the University of Pittsburgh’s Medical Center (UPMC), Mercy Hospital on April 23-24, 2010.
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Muscle pain, muscle weakness and Malignant Hyperthermia. Is There a Connection?
Dr. Henry Rosenberg MD, CPE
September 26, 2011

Surprising revelations concerning the association of MH with Drug induced muscle pain; muscle weakness with age; and an inherited syndrome of muscle weakness.

Comments (15)
Overview of drug induced hyperthermic syndromes other than MH (Part A)
Dr. Henry Rosenberg MD, CPE
August 16, 2011

In this month’s blog, I have asked Dr. Stanley Caroff, Professor of Psychiatry at the University of Pennsylvania, a long time member of MHAUS and prolific author on the subject of Neuroleptic Malignant Syndrome (NMS) to summarize several drug related reactions that resemble MH in some ways but are generally thought to be unrelated to the mechanisms that lead to MH.

Comments (4)
The European MH Group Meeting
Dr. Henry Rosenberg MD, CPE
June 21, 2011

I was privileged to attend the 30th Annual European MH Group (EMHG) meeting in the town of Nijmegen, Holland from June 8-10 this year. The EMHG was developed in the early 1980s by a group of clinical anesthesiologists and researchers interested in advancing the understanding of MH and providing optimum care to MH susceptibles and their families. The EMHG has focused on testing for MH susceptibility, muscle biopsy contracture tests as well as genetic tests and their relation to biochemical and physiologic changes that underlie the MH syndrome.

Comments (2)
An Overview of the First ever MH Hotline/Professional Advisory Council Meeting
Dr. Henry Rosenberg MD, CPE
May 31, 2011

On May 14, 2011 MHAUS sponsored the first ever day long retreat for our hotline and professional advisory consultants. 30 consultants, including one board member (Debra Merritt), a genetic counselor associated with the University of Pittsburgh MH DNA testing center (Deanna Steele) and Dr. Albert Urwyler, head of the MH testing center in Basel, Switzerland and member of the European MH group, met in a hotel near the Chicago O’Hare airport to discuss many perplexing issues related to MH.

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MHAUS is a Patient Safety Organization!
Dr. Henry Rosenberg MD, CPE
March 14, 2011

As part of my “day job” I am in charge of graduate medical education (i.e. residency programs) as well as medical student education at a large academic medical center.  In that capacity I and my colleagues who are supervising educational programs are required to keep up with the evolving standards that govern the training of the physicians of the future.

Comments (4)
The Doctor’s Dilemma-Part 2
Dr. Henry Rosenberg MD, CPE
February 18, 2011

Last month I discussed the difficulty of understanding how MH susceptibility relates to heat stroke, muscle breakdown with exercise and MH without anesthesia. This is an exceedingly complex and murky topic.

Comments (6)
The Doctor’s Dilemma
Dr. Henry Rosenberg MD, CPE
January 6, 2011

On behalf of MHAUS, its Board, Staff, Professional Advisory Council, and Hotline Consultants I would like to wish all of you a Happy and Healthy New Year. Our hope for the future is to fulfill the mission of eliminating death and disability related to MH and MH-related syndromes.

Comments (1)
Some New and Interesting Developments
Dr. Henry Rosenberg MD, CPE
November 10, 2010

First, I would like to apologize for the somewhat technical blog I posted for October, 2010. I realize that not everyone would be familiar enough with the science of MH and cellular physiology to understand some of the information behind my reasoning. However, in basic terms what I was trying to do was separate MH into subcategories based on what is known of the molecular biology and biochemistry of the disorder.  I realize too that not everyone would agree with my reasoning, but that is what a blog is for, i.e., theorizing and proposing some new ways of looking at things. 

Comments (8)
Towards a definition and classification of MH and MH-like syndromes
Dr. Henry Rosenberg MD, CPE
October 28, 2010

Malignant Hyperthermia (MH) is a life threatening syndrome characterized by hypermetabolism, hyperthermia, acidosis, muscle contraction, muscle membrane breakdown, hyperkalemia and rhabdomyolysis. The syndrome occurs as a result of exposure to certain drugs and /or environmental conditions.

Comments (4)
The mission of MHAUS is to promote optimum care and
scientific understanding of MH and related disorders.