Caffeine Halothane Contracture Test (CHCT)

The CHCT is the standard for MH diagnostic testing and is used to determine a patient’s susceptibility to MH.*

Patients must be referred to specialized CHCT Centers in order to have the special biopsy for CHCT performed.

MH experts generally feel a child less than 10 years old is not a good candidate for CHCT testing.

Muscle biopsies for CHCT must be performed at one of the designated CHCT testing centers because the test must be performed on fresh tissue.

CHCT cannot be performed on muscle samples sent via the mail.

*Allen, GC, Larach MG, Kunselman AR, and The North American Malignant Hyperthermia Registry of MHAUS: The sensitivity and specificity of the caffeine-halothane contracture test: A report from the North American Malignant Hyperthermia Registry. Anesthesiology 1998; 88:579-88. The online reference can be located at the Anesthesiology website archive March 1998.



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