Entries for month: August 2008

The Malignant HyperthermiaS

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The term Malignant Hyperthermia is most often applied to the syndrome that was first described in 1961 as a fatal reaction to general anesthesia. MH is the specific name given to the inherited disorder that leads individuals to develop a hypermetabolic reaction to certain general anesthetics and succinylcholine. And yes, a few individuals at risk for MH also experience problems resembling the MH syndrome with certain environmental stressors, such as heat and exercise. An MH reaction is terminated by the administration of dantrolene - a specific antidote for the MH reaction.

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