The following disorders have been shown to predispose a patient to MH:

• Central Core Disease and Multiminicore Disease. These patients should not receive MH triggers.
• Duchenne Muscular Dystrophy and Becker’s Muscular Dystrophy patients may develop life-threating hyperkalemia with succinylcholine and/ or potent volatile anesthetic agents, although this is not MH per se.
• The vast majority of muscle and neuromuscular disorders do not predispose the MH.
• Succinylcholine may precipitate muscle breakdown and /or rigidity (especially the myotonias). In general, succinylcholine should be avoided in all patients with clinical muscle or neuromuscular disorders. Mitochondrial myopathies do not predispose to MH.