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"Best Way to Mix Dantrolene"

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by: Brendan Frank
on 1/23/2007 at 6:59:31 PM

I am the medical director at an ambulatory surgery center. Today we had a mock MH drill and practiced mixing some expired Dantrolene. We tried to figure out the most efficient way to do this, but did not have very good luck. Does anybody have any suggestions? I read about using a sterile bowl. We tried using a fill kit used for saline breast implants. This worked OK, but not great. Any advice is appreciated. Thank you.


by: brendan frank
on 1/27/2007 at 4:14:18 PM

I have tried several methods since posting my question. Here's what appears to work the best.

Use liter bags of sterile water. Spike with a fill kit like those used to fill saline breast implants. Attach fill kit to propofol spike that has been inserted into Dantrolene vial. Use 60cc syringe to draw up the water and inject a full 60cc into each 20mg vial of Dantrolene. Leave the spike in the vial so somebody can shake the vial and then draw up the Dantrolene into another 60cc syringe. Administer the Dantrolene IV.


by: Eric Bryant
on 3/8/2008 at 6:01:16 PM

I am a Senior student at Samford University's nurse anesthesia program. I recently spoke on this topic as part of my Capstone project and found several articles pertaining to the reconstitution of Dantrolene. In one of the articles, the authors used a standard fluid warmer heated to 41 degrees C and ran a 1L bag of preservative-free sterile water through the warmer. At the end of the tubing, they attached a 3-way stopcock and a 60cc syringe for aspiration of the warmed diluent. The method sped the reconstitution time and was very simple to setup and aspirate the diluent. Baker K, Landriscina D, Kartchner H, Mirkes D. The Icarus effect: the influence of diluent warming on dantrolene sodium mixing time. AANA Journal. 2007;75:101-106